Maria Garcia Bonilla, PhD (Co-PI), Dave Limbrick, MD, PhD (Co-PI), and Pat McAllister, PhD at Washington University in St. Louis, USA, have received a 2-year $399,248 Discovery Award from the United States Department of Defense Peer Reviewed Medical Research Program entitled “Cerebrospinal Fluid Profiling in Preterm Infants with Hydrocephalus: Defining a Novel Pathway to Disability”. These studies will define the exosome and cell populations in the CSF from infants with post-hemorrhagic hydrocephalus and elucidate the relationship between inflammation, neurodevelopment, and hydrocephalus in mouse models, leading to new directions to improve outcomes for patients with this disabling condition. This project is recruiting students and colleagues.
Pat McAllister, PhD (Co-PI), Dave Limbrick, MD, PhD (Co-PI), and Maria Garcia Bonilla, PhD at Washington University in St. Louis, USA, have received a 5-year $3.2 million grant from the National Institutes of Health entitled “Experimental Studies of Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Hydrocephalus”. These comprehensive experimental comparisons of widespread, untested neurosurgical treatments will fill a critical void in hydrocephalus research, reveal the neurodevelopmental effects of ventricular shunting and ETV+CPC, and provide fundamental data to support best practices for the clinical management of pediatric hydrocephalus. This project is recruiting students and colleagues.
Recent relevant publications
- Garcia Bonilla M, Nair A, Moore J, Castaneyra Ruiz L, Zwick SH, Dilger RN, Fleming SA, Golden RK, Talcott MR, Isaacs AM, Limbrick DD Jr, McAllister JP II. Impaired neurogenesis ad reactive astrocytosis in the hippocampus in a porcine model of acquired hydrocephalus. Experimental Neurology, 2023 in press.
- Robert SM… Limbrick DD… Kahle KT et al. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 2023; 186(4):764-785.
- Karimy JK, Newville JC, Sadegh C, Morris JA, Monuki ES, Limbrick DD, McAllister JP, Koschnitzky JE, Lehtinen, MK, Jantzie LL. Outcomes of the 2019 hydrocephalus association workshop, “Driving common pathways: extending insights from posthemorrhagic hydrocephalus”. Fluids and Barriers of the CNS. 2023; 20(1):1. PMC
- McAllister JP II, Talcott M, Isaacs AM, Zwick SM, Garcia Bonilla M, Castaneyra Ruiz L, Hartman AL, Dilger RN, Fleming SA, Golden RK, Morales DM, Harris CA, Limbrick DD. A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments. Fluids and Barriers of the CNS. 2021; 18:49. PMCID: PMC8576945
- Garcia-Bonilla M, Castaneyra-Ruiz L, Zwick SH, Talcott M, Otum A, Isaacs AM, Morales DM, Limbrick DD Jr, McAllister JP II. Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter. Fluids and Barriers of the CNS. 2022; 19(17). PMCID: PMC8864805
- Khodadadei F, Arshad R, Morales DM, Gluski J, Marupudi NI, McAllister JP II, Limbrick DD Jr, Harris CA. The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure. Fluids and Barriers of the CNS 2022; 19(1):78.
- Limbrick DD Jr, de Vries LS. New insights into the management of post-hemorrhagic hydrocephalus. Seminars in Perinatology 2022; 46(5):151587.